| 1 | OpenAI | Frontier and model labs | 10 | 1,181,600 | February 2022 | Mission |
| 2 | Anthropic | Frontier and model labs | 8 | 944,955 | September 2021 | Financial District/South Beach |
| 3 | Sierra | AI-native applications | 3 | 392,239 | June 2023 | Financial District/South Beach |
| 4 | Databricks | AI infrastructure and tooling | 1 | 240,000 | August 2026 | Financial District/South Beach |
| 5 | Cognition | AI infrastructure and tooling | 2 | 205,000 | December 2025 | Financial District/South Beach |
| 6 | Physical Intelligence | Frontier and model labs | 4 | 185,964 | April 2024 | Mission |
| 7 | Scale AI | AI infrastructure and tooling | 2 | 180,000 | October 2021 | South of Market |
| 8 | Together AI | AI infrastructure and tooling | 2 | 180,000 | July 2023 | Mission Bay |
| 9 | Harvey | AI-native applications | 1 | 150,000 | July 2025 | Financial District/South Beach |
| 10 | Crusoe | AI infrastructure and tooling | 2 | 130,234 | August 2019 | Financial District/South Beach |
| 11 | Abridge | AI-native applications | 2 | 94,000 | January 2025 | Mission |
| 12 | Perplexity | AI-native applications | 2 | 80,561 | July 2024 | Financial District/South Beach |
| 13 | Thinking Machines | Frontier and model labs | 1 | 72,500 | January 2025 | Mission |
| 14 | LangChain | AI infrastructure and tooling | 2 | 70,000 | January 2023 | Financial District/South Beach |
| 15 | Decagon | AI-native applications | 1 | 69,358 | March 2026 | Financial District/South Beach |
| 16 | Hive | AI infrastructure and tooling | 2 | 57,000 | November 2020 | Financial District/South Beach |
| 17 | Bedrock Robotics | AI-native applications | 3 | 45,676 | June 2024 | Financial District/South Beach |
| 18 | Clay | AI-native applications | 1 | 44,000 | April 2024 | Financial District/South Beach |
| 19 | Nebius | AI infrastructure and tooling | 1 | 43,000 | August 2026 | Financial District/South Beach |
| 20 | Vercel | AI infrastructure and tooling | 2 | 42,147 | February 2024 | Financial District/South Beach |
| 21 | Hayden AI | AI-native applications | 1 | 41,000 | August 2023 | Financial District/South Beach |
| 22 | Exa | AI-native applications | 2 | 40,000 | May 2022 | Mission |
| 23 | Medra | AI-native applications | 2 | 38,042 | August 2024 | Mission |
| 24 | Flux | AI-native applications | 1 | 38,000 | March 2026 | Financial District/South Beach |
| 25 | Resolve AI | AI-native applications | 1 | 37,155 | August 2026 | Mission Bay |
| 26 | Salient | AI-native applications | 1 | 37,000 | June 2025 | North Beach |
| 27 | Cursor | AI-native applications | 5 | 35,562 | March 2024 | North Beach |
| 28 | Glean | AI-native applications | 1 | 30,000 | May 2025 | Financial District/South Beach |
| 29 | Fal.ai | AI infrastructure and tooling | 1 | 29,276 | June 2026 | Financial District/South Beach |
| 30 | Hex | AI-native applications | 2 | 28,500 | August 2023 | Chinatown |
| 31 | Mercor | AI infrastructure and tooling | 1 | 27,272 | November 2023 | Financial District/South Beach |
| 32 | Baseten | AI infrastructure and tooling | 2 | 26,000 | December 2022 | Financial District/South Beach |
| 33 | Reflection AI | Frontier and model labs | 2 | 25,000 | March 2026 | Financial District/South Beach |
| 34 | Giga | AI-native applications | 1 | 25,000 | June 2023 | Potrero Hill |
| 35 | Zyphra | Frontier and model labs | 1 | 25,000 | March 2026 | Financial District/South Beach |
| 36 | Midjourney | Frontier and model labs | 2 | 23,000 | February 2025 | Financial District/South Beach |
| 37 | Lambda | AI infrastructure and tooling | 1 | 20,000 | August 2026 | Financial District/South Beach |
| 38 | Distyl AI | AI-native applications | 1 | 17,511 | September 2025 | Financial District/South Beach |
| 39 | Unlearn.AI | AI-native applications | 1 | 17,200 | December 2023 | Financial District/South Beach |
| 40 | Recall.ai | AI infrastructure and tooling | 1 | 14,969 | February 2026 | South of Market |
| 41 | Chalk | AI infrastructure and tooling | 1 | 14,900 | December 2025 | Financial District/South Beach |
| 42 | Rad AI | AI-native applications | 2 | 11,500 | December 2022 | Chinatown |
| 43 | MindsDB | AI infrastructure and tooling | 1 | 11,000 | September 2023 | Mission |
| 44 | Cartesia | Frontier and model labs | 1 | 10,310 | July 2025 | Potrero Hill |
| 45 | EvenUp | AI-native applications | 1 | 10,300 | July 2025 | Financial District/South Beach |
| 46 | Greenlite AI | AI-native applications | 1 | 10,000 | August 2025 | Financial District/South Beach |
| 47 | Truewind | AI-native applications | 1 | 5,500 | March 2024 | Financial District/South Beach |
| 48 | LegalOn | AI-native applications | 1 | No public figure | December 2022 | Mission Bay |
| 49 | Anyscale | AI infrastructure and tooling | 1 | No public figure | July 2025 | Financial District/South Beach |
| 50 | Assort Health | AI-native applications | 1 | No public figure | May 2023 | Chinatown |
| 51 | CodeRabbit | AI infrastructure and tooling | 1 | No public figure | September 2025 | Financial District/South Beach |
| 52 | HappyRobot | AI-native applications | 1 | No public figure | November 2024 | Potrero Hill |
| 53 | Leena AI | AI-native applications | 1 | No public figure | October 2022 | Financial District/South Beach |
| 54 | Rescale | AI infrastructure and tooling | 1 | No public figure | January 2025 | South of Market |
| 55 | DataRobot | AI infrastructure and tooling | 1 | No public figure | February 2022 | Financial District/South Beach |
| 56 | Adept AI Labs | Frontier and model labs | 1 | No public figure | January 2022 | Mission |
| 57 | Artos | AI-native applications | 1 | No public figure | November 2023 | Mission Bay |
| 58 | Autify | AI-native applications | 1 | No public figure | May 2024 | Tenderloin |
| 59 | Butter Payments | AI-native applications | 1 | No public figure | April 2020 | Presidio |
| 60 | depthfirst | AI-native applications | 1 | No public figure | April 2026 | Financial District/South Beach |
| 61 | Expedock | AI-native applications | 1 | No public figure | January 2022 | Financial District/South Beach |
| 62 | Gamma | AI-native applications | 1 | No public figure | March 2025 | Potrero Hill |
| 63 | Harmonic Security | AI-native applications | 1 | No public figure | August 2023 | Financial District/South Beach |
| 64 | HumanSignal | AI infrastructure and tooling | 1 | No public figure | April 2026 | Financial District/South Beach |
| 65 | Labelbox | AI infrastructure and tooling | 1 | No public figure | September 2019 | Mission |
| 66 | Levelpath | AI-native applications | 1 | No public figure | March 2022 | Financial District/South Beach |
| 67 | Nimble Robotics | AI-native applications | 1 | No public figure | February 2021 | South of Market |
| 68 | Plenful | AI-native applications | 1 | No public figure | March 2021 | Financial District/South Beach |
| 69 | Reducto | AI-native applications | 1 | No public figure | July 2026 | Financial District/South Beach |
| 70 | Surge AI | AI infrastructure and tooling | 1 | No public figure | June 2020 | Financial District/South Beach |
| 71 | Trellis AI | AI-native applications | 1 | No public figure | October 2023 | Financial District/South Beach |
| 72 | Valerie Health | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 73 | Voltage Park | AI infrastructure and tooling | 1 | No public figure | November 2024 | Chinatown |
| 74 | ElevenLabs | Frontier and model labs | 1 | No public figure | March 2025 | Financial District/South Beach |
| 75 | Triomics | AI-native applications | 2 | No public figure | January 2021 | Chinatown |
| 76 | Ambient.ai | AI-native applications | 1 | No public figure | July 2021 | Financial District/South Beach |
| 77 | Cambio | AI-native applications | 1 | No public figure | August 2026 | Chinatown |
| 78 | OpusClip | AI-native applications | 1 | No public figure | January 2025 | Chinatown |
| 79 | Supio | AI-native applications | 1 | No public figure | February 2026 | Financial District/South Beach |
| 80 | Spot AI | AI-native applications | 1 | No public figure | April 2025 | South of Market |
| 81 | Inscribe | AI-native applications | 1 | No public figure | March 2020 | Financial District/South Beach |
| 82 | Edison Scientific | AI-native applications | 1 | No public figure | June 2025 | Bayview Hunters Point |
| 83 | AgentCollect | AI-native applications | 1 | No public figure | April 2025 | Nob Hill |
| 84 | Alpharun | AI-native applications | 1 | No public figure | July 2024 | Financial District/South Beach |
| 85 | Altara | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 86 | Archil | AI-native applications | 1 | No public figure | October 2025 | Financial District/South Beach |
| 87 | AthenaHQ | AI-native applications | 1 | No public figure | December 2025 | Financial District/South Beach |
| 88 | Atmo | AI-native applications | 1 | No public figure | September 2023 | South of Market |
| 89 | Brisk Teaching | AI-native applications | 1 | No public figure | March 2023 | Mission Bay |
| 90 | Browserbase | AI infrastructure and tooling | 1 | No public figure | January 2024 | Financial District/South Beach |
| 91 | Bunkerhill Health | AI-native applications | 1 | No public figure | March 2020 | Financial District/South Beach |
| 92 | CommodityAI | AI-native applications | 1 | No public figure | April 2024 | Mission Bay |
| 93 | Corridor | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 94 | Crossing Minds | AI-native applications | 1 | No public figure | January 2017 | South of Market |
| 95 | CTGT | AI infrastructure and tooling | 1 | No public figure | August 2025 | Financial District/South Beach |
| 96 | Dashworks | AI-native applications | 1 | No public figure | November 2019 | Financial District/South Beach |
| 97 | Eloquent AI | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 98 | General Compute | AI infrastructure and tooling | 1 | No public figure | October 2026 | South of Market |
| 99 | Goodfire AI | AI infrastructure and tooling | 1 | No public figure | June 2024 | Financial District/South Beach |
| 100 | Hyperbound | AI-native applications | 1 | No public figure | February 2025 | Financial District/South Beach |
| 101 | Industrial Next | AI-native applications | 1 | No public figure | January 2024 | South of Market |
| 102 | Leaping AI | AI-native applications | 1 | No public figure | January 2025 | Chinatown |
| 103 | Mach9 | AI-native applications | 1 | No public figure | November 2024 | South of Market |
| 104 | Mem0 | AI-native applications | 1 | No public figure | June 2024 | Financial District/South Beach |
| 105 | OneSchema | AI-native applications | 1 | No public figure | August 2021 | Tenderloin |
| 106 | SalesPatriot | AI-native applications | 1 | No public figure | December 2024 | Financial District/South Beach |
| 107 | Sieve | AI infrastructure and tooling | 1 | No public figure | March 2023 | Financial District/South Beach |
| 108 | Solidroad | AI-native applications | 1 | No public figure | March 2025 | North Beach |
| 109 | Strada | AI-native applications | 1 | No public figure | March 2024 | Financial District/South Beach |
| 110 | Town | AI-native applications | 1 | No public figure | February 2025 | Financial District/South Beach |
| 111 | UniversalAGI | AI-native applications | 1 | No public figure | August 2025 | Financial District/South Beach |
| 112 | Unsloth AI | AI infrastructure and tooling | 1 | No public figure | December 2024 | Chinatown |
| 113 | VeriSIM Life | AI-native applications | 1 | No public figure | September 2023 | Financial District/South Beach |
| 114 | Watney Robotics Inc | AI-native applications | 1 | No public figure | January 2025 | Mission |
| 115 | TaxGPT | AI-native applications | 1 | No public figure | February 2024 | South of Market |
| 116 | AssemblyAI | Frontier and model labs | 1 | No public figure | January 2019 | Inner Sunset |
| 117 | Campfire | AI-native applications | 1 | No public figure | January 2024 | Financial District/South Beach |
| 118 | Genmo | Frontier and model labs | 1 | No public figure | July 2024 | Financial District/South Beach |
| 119 | Luthor | AI-native applications | 1 | No public figure | December 2024 | Mission |
| 120 | OpenEvidence | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 121 | World Labs | Frontier and model labs | 1 | No public figure | December 2023 | Financial District/South Beach |
| 122 | ArchiLabs | AI-native applications | 1 | No public figure | January 2025 | Mission Bay |
| 123 | BootLoop | AI-native applications | 1 | No public figure | January 2026 | Nob Hill |
| 124 | Corelayer | AI-native applications | 1 | No public figure | April 2026 | Marina |
| 125 | Entvin | AI-native applications | 1 | No public figure | January 2026 | Chinatown |
| 126 | Fazeshift | AI-native applications | 1 | No public figure | June 2024 | Financial District/South Beach |
| 127 | Frigade | AI-native applications | 1 | No public figure | June 2025 | South of Market |
| 128 | Halluminate | AI infrastructure and tooling | 1 | No public figure | June 2026 | Potrero Hill |
| 129 | Kino AI | AI-native applications | 1 | No public figure | October 2024 | Chinatown |
| 130 | Log10 | AI-native applications | 1 | No public figure | December 2023 | Marina |
| 131 | Navier AI | AI-native applications | 1 | No public figure | November 2024 | Financial District/South Beach |
| 132 | Palmier | AI-native applications | 1 | No public figure | September 2024 | Financial District/South Beach |
| 133 | Parley | AI-native applications | 1 | No public figure | March 2025 | Financial District/South Beach |
| 134 | RiskCube | AI-native applications | 1 | No public figure | February 2025 | Castro/Upper Market |
| 135 | Stoa | AI infrastructure and tooling | 1 | No public figure | October 2026 | Financial District/South Beach |
| 136 | Traceforce | AI-native applications | 1 | No public figure | February 2025 | Financial District/South Beach |
| 137 | Tusk | AI-native applications | 1 | No public figure | January 2025 | Mission |
| 138 | Vybe | AI-native applications | 1 | No public figure | February 2026 | South of Market |
| 139 | Wayfound | AI infrastructure and tooling | 1 | No public figure | February 2026 | Chinatown |
| 140 | Yoneda Labs | AI-native applications | 1 | No public figure | May 2024 | Potrero Hill |
| 141 | Rosebud AI | AI-native applications | 2 | No public figure | January 2024 | Financial District/South Beach |
| 142 | Andon Labs | AI infrastructure and tooling | 1 | No public figure | November 2025 | Marina |
| 143 | Lucidic AI | AI infrastructure and tooling | 1 | No public figure | July 2026 | Financial District/South Beach |
| 144 | Ligo Biosciences | AI-native applications | 2 | No public figure | January 2026 | Potrero Hill |
| 145 | VVESSL AI | AI infrastructure and tooling | 2 | No public figure | November 2025 | Financial District/South Beach |
| 146 | Weights & Biases | AI infrastructure and tooling | 2 | No public figure | July 2021 | Mission |
| 147 | AAcross AI | AI-native applications | 1 | No public figure | October 2024 | Financial District/South Beach |
| 148 | AdsGency AI | AI-native applications | 1 | No public figure | August 2025 | Financial District/South Beach |
| 149 | Agave | AI-native applications | 1 | No public figure | August 2025 | Financial District/South Beach |
| 150 | AAgentHub | AI infrastructure and tooling | 1 | No public figure | March 2026 | Chinatown |
| 151 | Airbyte | AI-native applications | 1 | No public figure | January 2024 | Financial District/South Beach |
| 152 | Anthrogen | Frontier and model labs | 1 | No public figure | August 2026 | South of Market |
| 153 | Applied Intuition | AI-native applications | 1 | No public figure | April 2025 | Potrero Hill |
| 154 | AArchiboost AI | AI-native applications | 1 | No public figure | June 2025 | Financial District/South Beach |
| 155 | AArtificial Analysis | AI infrastructure and tooling | 1 | No public figure | January 2025 | Financial District/South Beach |
| 156 | AAstorie | AI-native applications | 1 | No public figure | September 2026 | Chinatown |
| 157 | Automat | AI-native applications | 1 | No public figure | September 2025 | Mission |
| 158 | Backflip AI | AI-native applications | 1 | No public figure | April 2025 | Financial District/South Beach |
| 159 | BBackOps | AI-native applications | 1 | No public figure | September 2026 | Financial District/South Beach |
| 160 | Bretton AI | AI-native applications | 1 | No public figure | May 2025 | Financial District/South Beach |
| 161 | Chai Discovery | Frontier and model labs | 1 | No public figure | November 2025 | Financial District/South Beach |
| 162 | Chef Robotics | AI-native applications | 1 | No public figure | April 2025 | Mission Bay |
| 163 | CCline | AI infrastructure and tooling | 1 | No public figure | July 2025 | Mission Bay |
| 164 | Contrario | AI-native applications | 1 | No public figure | April 2026 | Financial District/South Beach |
| 165 | Corgi | AI-native applications | 1 | No public figure | February 2024 | Financial District/South Beach |
| 166 | Corvera | AI-native applications | 1 | No public figure | January 2026 | Financial District/South Beach |
| 167 | Decisional AI | AI-native applications | 1 | No public figure | March 2025 | South of Market |
| 168 | Deepnight | AI-native applications | 1 | No public figure | November 2025 | Financial District/South Beach |
| 169 | DDeepScribe | AI-native applications | 1 | No public figure | January 2020 | North Beach |
| 170 | DDiffuseDrive | AI infrastructure and tooling | 1 | No public figure | January 2025 | Financial District/South Beach |
| 171 | Domino Data Lab | AI infrastructure and tooling | 1 | No public figure | November 2016 | South of Market |
| 172 | Dynamo AI | AI-native applications | 1 | No public figure | May 2026 | Chinatown |
| 173 | EEffective AI | AI-native applications | 1 | No public figure | July 2025 | Financial District/South Beach |
| 174 | EEllipsis Health | AI-native applications | 1 | No public figure | January 2021 | Financial District/South Beach |
| 175 | EEmissary | AI infrastructure and tooling | 1 | No public figure | March 2026 | Chinatown |
| 176 | EExamen | AI-native applications | 1 | No public figure | April 2025 | Marina |
| 177 | Flai | AI-native applications | 1 | No public figure | April 2026 | Mission |
| 178 | FleetWorks | AI-native applications | 1 | No public figure | June 2022 | Bayview Hunters Point |
| 179 | flowscope | AI-native applications | 1 | No public figure | October 2026 | Financial District/South Beach |
| 180 | Fluently | AI-native applications | 1 | No public figure | May 2024 | Mission Bay |
| 181 | FurtherAI | AI-native applications | 1 | No public figure | September 2025 | Mission Bay |
| 182 | GGimlet Labs | AI infrastructure and tooling | 1 | No public figure | July 2025 | Mission |
| 183 | GGraphon Labs | AI infrastructure and tooling | 1 | No public figure | July 2025 | Financial District/South Beach |
| 184 | HHanomi | AI-native applications | 1 | No public figure | October 2025 | Financial District/South Beach |
| 185 | Hebbia | AI-native applications | 1 | No public figure | September 2025 | Financial District/South Beach |
| 186 | HHobbes | AI-native applications | 1 | No public figure | January 2025 | Financial District/South Beach |
| 187 | HHyperbolic | AI infrastructure and tooling | 1 | No public figure | January 2024 | Financial District/South Beach |
| 188 | IInfinitus Systems, Inc. | AI-native applications | 1 | No public figure | August 2025 | Financial District/South Beach |
| 189 | Julius | AI-native applications | 1 | No public figure | January 2026 | Financial District/South Beach |
| 190 | KKenley | AI-native applications | 1 | No public figure | February 2025 | Chinatown |
| 191 | KKinro | AI-native applications | 1 | No public figure | December 2025 | Mission |
| 192 | Klarity | AI-native applications | 1 | No public figure | June 2023 | Financial District/South Beach |
| 193 | LlamaIndex | AI infrastructure and tooling | 1 | No public figure | May 2023 | South of Market |
| 194 | MMarqo | AI infrastructure and tooling | 1 | No public figure | May 2024 | Financial District/South Beach |
| 195 | Mechanize, Inc. | AI infrastructure and tooling | 1 | No public figure | April 2025 | Financial District/South Beach |
| 196 | MMedeloop | AI-native applications | 1 | No public figure | January 2025 | Chinatown |
| 197 | MMission Control AI | AI-native applications | 1 | No public figure | February 2025 | Financial District/South Beach |
| 198 | NNiantic Spatial, Inc. | Frontier and model labs | 1 | No public figure | May 2025 | Financial District/South Beach |
| 199 | OOne Robot | AI infrastructure and tooling | 1 | No public figure | February 2026 | Mission |
| 200 | Opslane | AI infrastructure and tooling | 1 | No public figure | March 2025 | Mission Bay |
| 201 | Pax | AI-native applications | 1 | No public figure | December 2025 | Financial District/South Beach |
| 202 | PPickaxe | AI infrastructure and tooling | 1 | No public figure | August 2025 | Mission |
| 203 | Polymath Robotics | AI-native applications | 1 | No public figure | June 2024 | Mission |
| 204 | RReactor | AI infrastructure and tooling | 1 | No public figure | March 2026 | South of Market |
| 205 | Relling | AI-native applications | 1 | No public figure | February 2026 | Potrero Hill |
| 206 | Replicate | AI-native applications | 1 | No public figure | September 2023 | Mission |
| 207 | Risely AI | AI-native applications | 1 | No public figure | June 2026 | South of Market |
| 208 | RRoadrunner | AI-native applications | 1 | No public figure | August 2025 | Financial District/South Beach |
| 209 | Runway | Frontier and model labs | 1 | No public figure | February 2024 | Financial District/South Beach |
| 210 | SafetyKit | AI-native applications | 1 | No public figure | June 2026 | Mission |
| 211 | SigOpt | AI infrastructure and tooling | 1 | No public figure | August 2018 | Financial District/South Beach |
| 212 | SSolvely.ai | AI-native applications | 1 | No public figure | March 2025 | Financial District/South Beach |
| 213 | SSymbolica AI | AI infrastructure and tooling | 1 | No public figure | August 2024 | Financial District/South Beach |
| 214 | Synth | AI infrastructure and tooling | 1 | No public figure | October 2024 | Mission Bay |
| 215 | TAZI AI Systems | AI-native applications | 1 | No public figure | January 2022 | Financial District/South Beach |
| 216 | Toma | AI-native applications | 1 | No public figure | May 2025 | Mission Bay |
| 217 | TTonic.ai | AI infrastructure and tooling | 1 | No public figure | June 2018 | Financial District/South Beach |
| 218 | Uplane | AI-native applications | 1 | No public figure | March 2026 | Chinatown |
| 219 | VValence AI | AI-native applications | 1 | No public figure | July 2024 | Financial District/South Beach |
| 220 | Vapi | AI-native applications | 1 | No public figure | January 2021 | Financial District/South Beach |
| 221 | VVoxel | AI-native applications | 1 | No public figure | October 2021 | Financial District/South Beach |
| 222 | Woebot Health | AI-native applications | 1 | No public figure | November 2022 | Financial District/South Beach |
| 223 | YYou.com | AI-native applications | 1 | No public figure | December 2025 | Financial District/South Beach |